Search results for "Homogeneous clusters"
showing 2 items of 2 documents
FragClust and TestClust, two informatics tools for chemical structure hierarchical clustering analysis applied to lipidomics. The example of Alzheime…
2016
Lipidomic analysis is able to measure simultaneously thousands of compounds belonging to a few lipid classes. In each lipid class, compounds differ only by the acyl radical, ranging between C10:0 (capric acid) and C24:0 (lignoceric acid). Although some metabolites have a peculiar pathological role, more often compounds belonging to a single lipid class exert the same biological effect. Here, we present a lipidomics workflow that extracts the tandem mass spectrometry data from individual files and uses them to group compounds into structurally homogeneous clusters by chemical structure hierarchical clustering analysis (CHCA). The case-to-control peak area ratios of the metabolites are then a…
Classifying Regions for European Development Funding
2010
Structural and cohesion funds play a prominent role in European Union regional policy, which aims to reduce gaps in development between regions and disparities in well-being between European citizens. The regions and areas eligible for funding — 308,000 million during the 2007—13 period — are chosen according to regional GDP per inhabitant as the variable of reference. Despite the great importance of this indicator, the complex socioeconomic reality of regions cannot be fully explained by means of a single variable. Hence, using the large number of variables on economic, political, cultural and demographic characteristics available at regional level, this article groups European regions in…